RESUMO
When a patient with a previous history of neoplasm presents with a thyroid lesion, the possibility of it being metastatic should always be considered. In this series, we present the clinicopathological and immunohistochemical features of the thyroid metastases diagnosed in our department over the past 30 years. Here we present eight thyroidal metastases from clear cell renal cell carcinoma (ccRCCC), including a tumor to tumor metastasis, the patients being 2 men and 6 women with a median age of 62 years. The majority had a past history of goiter and a single and palpable metastasis. In one patient the thyroid metastases were the first sign of the ccRCCC. In the available cases, the metastasis showed positivity to PAX8 and CAIX and negativity to TTF1 and thyroglobulin. The median time from the detection of the primary renal tumor to thyroid metastasis and from thyroidectomy to last follow up were 84.17 and 54.50 months, respectively. After a median follow up of 158.50 months none of the patients had died from ccRCCC. Renal cell carcinoma (RCC) is the most frequent malignant neoplasm of the kidney and its incidence has increased over recent decades. In a clinical series, up to 1-3% of the oncologic thyroidectomies were due to thyroid metastases and the most frequent metastasizing tumor was RCC, followed by lung and breast cancer
Todas las lesiones de tiroides en pacientes con una historia previa de neoplasia, deberían ser estudiadas como metastásicas. En esta serie, presentamos las características clínico-patológicas e inmunohistológicas de las metástasis encontradas en tiroides en los últimos 30 años. Se presentan 8 metástasis de carcinoma de células renales de tipo células claras en tiroides (CcRCCc), incluyendo una metástasis de tumor a tumor, correspondiendo a 2 varones y 6 mujeres con una edad media de 62 años. La mayoría tuvo una historia previa de bocio y un tumor único y palpable. La metástasis tiroidea fue el primer signo clínico de CcRCCc en uno de los pacientes. Cuando fue posible realizar un estudio inmunohistoquímico, las metástasis fueron positivas para PAX8 y CAIX, y negativas para TTF1 y tiroglobulina. El tiempo medio desde el diagnóstico del tumor primario hasta la presencia de metástasis en tiroides, y desde la tiroidectomía hasta la última revisión fue de 84,17 y 54,50 meses, respectivamente. Después de un tiempo medio de seguimiento de 158,50 meses, ningún paciente falleció a causa de CcRCCc. El carcinoma de células renales (CCR) es la neoplasia maligna más frecuente del riñón, cuya incidencia ha aumentado durante las últimas décadas. En una serie, hasta el 1-3% de las tiroidectomías oncológicas fueron por metástasis. El tumor metastatizante más común fue el CCR, seguido de pulmón y mama
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Neoplasias da Glândula Tireoide/patologia , Carcinoma de Células Renais/patologia , Neoplasias Renais/patologia , Estudos Retrospectivos , Neoplasias da Glândula Tireoide/secundário , Metástase Neoplásica/patologiaRESUMO
When a patient with a previous history of neoplasm presents with a thyroid lesion, the possibility of it being metastatic should always be considered. In this series, we present the clinicopathological and immunohistochemical features of the thyroid metastases diagnosed in our department over the past 30 years. Here we present eight thyroidal metastases from clear cell renal cell carcinoma (ccRCCC), including a tumor to tumor metastasis, the patients being 2 men and 6 women with a median age of 62 years. The majority had a past history of goiter and a single and palpable metastasis. In one patient the thyroid metastases were the first sign of the ccRCCC. In the available cases, the metastasis showed positivity to PAX8 and CAIX and negativity to TTF1 and thyroglobulin. The median time from the detection of the primary renal tumor to thyroid metastasis and from thyroidectomy to last follow up were 84.17 and 54.50 months, respectively. After a median follow up of 158.50 months none of the patients had died from ccRCCC. Renal cell carcinoma (RCC) is the most frequent malignant neoplasm of the kidney and its incidence has increased over recent decades. In a clinical series, up to 1-3% of the oncologic thyroidectomies were due to thyroid metastases and the most frequent metastasizing tumor was RCC, followed by lung and breast cancer.
